AbstractResumenContext: The importance of traditional medicine cannot be over emphasizedas a quarter of prescription drugs globally are natural based. In this type of medicine, plants aremixed together or are sometimes used in combination withother materials such as animals and minerals, as remedy. While a considerable amount of documentation of indigenous knowledge of medicinal plants has been executed, there is paucity of similar studieson animals in Nigeria.Aims: To carry outa survey of ethnozoology among the Epie-Atissa and Ogbia people of Bayelsa State, Nigeria, with a view to documenting species with zoo-therapeutic values.Methods: Using a semi-structured questionnaire, information was gathered through personal interviews with traditional medical practitioners. The data were evaluated using some ethnozoological indices such as use value of the species, family use value, relative frequency of citation, relative number of use, relative importance index, and cultural importance (CI).Results: A total of 43 species of animals belonging to three phyla, Chordata(66.7%), Arthropoda(22.2%) and Molluscaand Pisces(15.9%) were gathered in ten classes with Mammaliabeing the most mentioned (22.7%) followed by Reptilia(18.2%) and Pisces(15.9%). The most important diseases cited were inflammation/pain/arthritis (20.0%), ear/nose/throat (18.3%), reproductive purpose (16.7%) and convulsion/epilepsy (15.0%) while the most culturally important animals (CI) included Agama agama(0.85), Protopterus dolloi (0.45), Testudo graeca (0.23), Gorilla gorilla(0.17), Hemachatus haemachatus (0.14) and Hemidactylus frenatus (0.14).Conclusions: The survey furnishes the populace including medicinal plant researchers and some other traditional medicine practitioners with a real wellspring of communicable knowledge. These medicinal animal materials could be included in the healthcare delivery system of the country.